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Finally, one trial in 239 participants already suffering from chemotherapy-induced peripheral neuropathy reported a reduction in the severity of neuropathic symptoms with ALCAR (3 g/day for eight weeks) compared to placebo (93)

Dysregulation of ketone metabolism contributes to the pathologies of some cardiometabolic diseases and can lead to insulin resistance

Neumann, J

Thus, while acute LC supplementation may confer immediate physiological benefits, chronic elevations in TMAO levels warrant careful risk evaluation due to their association with adverse cardiovascular outcomes, particularly in vulnerable populations

Research has also shown that, in hypothyroid patients, there was indeed a trend for muscle carnitine content to be lower than normal, and that carnitine levels improved with thyroid hormone treatment