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In contrast, an earlier meta-analysis from the Emerging Risk Factors Collaboration found LDL-C, Non-HDL and apoB to be equivalent markers of CVE (474)

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Mechanistically, TMAO exacerbates IBD pathogenesis by modulating key signaling pathwaysincluding endoplasmic reticulum stress (ERS) via protein kinase RNA-like endoplasmic reticulum kinase (PERK) activation, NF-B-driven proinflammatory cytokine production, and NLRP3 inflammasome-mediated pyroptosisthereby disrupting intestinal epithelial integrity, amplifying macrophage and T cell activation, and skewing immune homeostasis toward a proinflammatory milieu

1 Introduction As a conditionally essential nutrient, L-carnitine has an important role in human fat metabolism
