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doi: 10.1177/1933719118766259
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After a closed head injury, ApoE / mice exhibit elevated levels of iron in their brains, suggesting that ApoE / deficiency may increase the risk of oxidative damage to hippocampal tissue ( In vitro studies show that upregulating sestrin2 decreases type I/II collagen and KEAP1 mRNA expression while increasing GPX4 and Nrf2 mRNA levels
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It has also been reported in several studies that GA has antianxiety (Meftahi and Aboutaleb 2023
