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In a study by Ray et al

For example, hyperglycemia increases the O-GlcNAc modification of calcium/calmodulin-dependent protein kinase II (CaMKII), which in turn leads to the autonomous activation of CaMKII ( 2+ leakage, improved cardiac contractility, and reduced arrhythmia events ( Figure 2 In summary, calcium plays an important role in cardiac dysfunction caused by ROS derived under the condition of hyperglycemia

Monteleone M, Stanley AC, Chen KW, Brown DL, Bezbradica JS, von Pein JB, Holley CL, Boucher D, Shakespear MR, Kapetanovic R, et al

Characterization of TGF-beta expression and signaling profile in the adipose tissue of rats fed with high-fat and energy-restricted diets

The results showed that fur gene-based phylogenetic trees produced topologies more consistent with the recognized taxonomy of the Burkholderia genus than those based on 16S rRNA gene sequencing