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Description
Another mutation found in certain forms of hereditary hemochromatosis also affects the HFE gene and causes a change of His 63 to Asp (referred to as the H63D allele)
This multiprotein complex activates executioner caspases, such as caspase-3, initiating a cascade of proteolytic events that ultimately lead to the programmed death and clearance of damaged neurons (106)

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Interestingly, infants with congenital GH deficiency and GHR mutations present with only minor growth retardation, whereas the rare patient with IGF-I deficiency, secondary to a homozygous partial deletion of the IGF-I gene, presents with severe pre and postnatal growth failure, mental retardation, sensorineural deafness, and microcephaly (76-78)

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