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[DOI] [PMC free article] [PubMed] [Google Scholar] 130.Caas A., Lpez-Snchez L.M., Pearando J., Valverde A., Conde F.M., Hernndez V., Fuentes E., Lpez-Pedrera C., De La Haba-Rodrguez J.R., Aranda E., et al

The initial inflammatory phase is characterized by platelet activation, the recruitment of immune cells, the release of growth factors and cytokine, followed by the secretion of growth factors and enhanced cell proliferation, and finally, in a remodeling phase, collagen production and histogenesis leads to mature scars (125)

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674 In a TBI mouse model, HBED treatment can reduce microglia proliferation and aquaporin 4 expression, thereby alleviating secondary injury in the cortical region after TBI and improving motor function in mice