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The membrane-bound folate receptor has the highest affinity for folate (Kd 0.11 nmol/l), characteristically binds folic acid, reduced folates, many antifolate drugs, and folate conjugates, and transports them by a non-classical endocytic mechanism 881,885

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quality and dosing of compounded or research material vary

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It may also interact with nitric oxide pathways that affect blood vessels and inflammation

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