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Conversely, we intraperitoneally injected DL-buthionine-(S,R)-sulfoximine (BSO), which is a small molecule that effectively inhibits GSH synthesis [29], to treat mice after dorsal hair plucking and observed that BSO treatment led to decreased GSH content (Fig

In order to gain insight into the antioxidant capacity of the cells tested, in our study we also controlled the level of sulfane sulfur, as well as the levels of low-molecular-weight, non-protein sulfur-containing compounds, such as the oxidized and reduced form of glutathione, cysteine ad cystine

Melatonin Physiology Seasonal Rhythms A truly distinct physiological role for melatonin was initially indicated by the fact that pinealectomy or ganglionectomy (which abolished the rhythm of circulating melatonin) abolished the ability of photoperiodic mammals to time seasonal physiology according to the day length (with very rare exceptions) (39, 40)

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Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass