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The axonal guidance and Wnt/-catenin signaling contribute to the loss of dopaminergic neurons and the increased -synuclein, identified by transcriptome sequencing in the ventral midbrain and striatum of PQ treated mice (Gollamudi et al., 2012)

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This enzymatic defect reduces synthesis of glutathione and the resulting low intracellular glutathione levels remove the normal tonic inhibition of the enzyme -glutamylcysteine synthetase (Figure 1 and Figure 2, reaction 4)

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Unlike NAD+ precursors, researchers study 5-Amino-1MQ mainly for how it interacts with the NNMT enzyme

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