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The axonal guidance and Wnt/-catenin signaling contribute to the loss of dopaminergic neurons and the increased -synuclein, identified by transcriptome sequencing in the ventral midbrain and striatum of PQ treated mice (Gollamudi et al., 2012)

This enzymatic defect reduces synthesis of glutathione and the resulting low intracellular glutathione levels remove the normal tonic inhibition of the enzyme -glutamylcysteine synthetase (Figure 1 and Figure 2, reaction 4)

Shi Z, Zhao Z, Shu Q: Protective effect of recombinant beta-defensin-2 on acute lung injury induced by sepsis in rats

Unlike NAD+ precursors, researchers study 5-Amino-1MQ mainly for how it interacts with the NNMT enzyme
