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The investigator who assessed results from photographs was blinded (did not know which group each patient was in), adding objectivity to the evaluation

Y.ChoiJ.JunS.ShkreliM.et al

What is the concentration of a drug following 6 hr of administration

In the acute evaluation, performed with mice, the authors presented a medium lethal dose (LD 50 ) of 720 66.4 mg/kg, despite declaring that the study does not show any toxic symptoms, changes in behavior or mortality at the tested doses. For 1N2PE, LD50 of 712 17.39 mg/kg for oral administration (Oyemitan et al., 2013)

2021;11:1263 Horowitz JR, Rivard A, van der Zee R, Hariawala M, Sheriff DD, Esakof DD, et al