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Description
SF has been shown to prevent tert-butyl hydroperoxide-induced mitochondrial permeability transition pore opening in rat brain and liver mitochondria, and to protect against mitochondrial dysfunction caused by lipid peroxidation byproducts like 4-hydroxynonenal [127]
Lipid peroxidation is a marker of oxidate stress, and the product 4-hydroxy-2-nonenal (4HNE) is increased in the lung tissue of COPD patients, indicating the local production of ROS [24]
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Protein kinase R-like endoplasmic reticulum kinase (PERK) activation triggers eukaryotic initiation factor 2 alpha (eIF2) phosphorylation specifically at serine 51, leading to selective mRNA translation despite global protein synthesis attenuation
Blood-brain-barrier-penetrant AngIV analog Studied as a metabolically stabilized, orally active angiotensin-IV derivative designed to reach the brain in animal pharmacokinetic work
