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Recognizing this duality highlights the need for a comprehensive approach that balances symptom relief with potential impacts on gut health, ensuring that interventions contribute positively to the multifactorial nature of ME/CFS [7]

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Early detection helps prevent long-term symptoms

Receptor Binding and Downstream Signaling IGF-1 LR3 binds IGF1R with affinity similar to native IGF-1, preserving the receptor-level pharmacology while altering the pharmacokinetics

Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B12 deficiency