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Pharmacogenetic indicators, such as polymorphisms in DPYD, TYMS, GSTP1, and ABCC2, have been linked to toxicity in patients undergoing fluoropyrimidine and oxaliplatin-based treatments [269, 270]

doi: 10.1002/ptr.2523

Nutmeg [29] Okinawamozuku ( Cladosiphon okamuranus ), edible seaweed from Okinawa, effective in Mongolian gerbils [50]

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154,155 These opioid agonists also disrupt the endocrine system: methadone has been shown to disturb the hypothalamic pituitary gonadal axis, 156,157 and buprenorphine has not been adequately studied in respect to its long-term effects on the hypothalamic-pituitary-adrenal (HPA) axis as noted in a 2018 literature review by Varma et al