glutathione s transferases and drug resistance Frontiers Glutathione-S-Transferases as Potential Targets for

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On the other hand, when it occurs in the mitochondria, the conversion of 5,10-MTHF into 10-formyl-THF is catalyzed by methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) or methylenetetrahydrofolate dehydrogenase 2-like (MTHFD2L), which exhibit bifunctional cyclohydrolase and dehydrogenase activities, with NADP + reduction to NADPH

Its mechanism involves the use of high-energy ionizing radiation (IR) to induce DNA fragmentation in tumor cells and subsequent initiation of various intracellular signal transduction pathways, including oxidative stress, the inflammatory response, and apoptosis ( Therefore, strategies are needed to effectively kill radioresistant tumor cells and improve their sensitivity to radiotherapy

The PBMCs of allergic rhinitis patients pre-treated with luteolin (1.25, 2.5, 5 g/mL) reduced CD4+IL-4- secreting cells at 5 g/mL, confirming luteolins inhibition of Th2 cells expression [162]