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AOD-9604 does not cause receptor desensitization or hormonal suppression, so the break is precautionary rather than biologically required

Clinical evidence: in a cohort study involving 4,125 elderly individuals, higher cereal-derived RS intake (15 g/day) was associated with a 28% reduction in serum IL-6 levels and a 35% reduction in TNF- levels compared to low-RS intake ( 90%sufficient to meet 25% of daily protein requirements and support tryptophan (serotonin precursor) and tyrosine (dopamine precursor) supply (304)

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Metabolic alterations of the immune system in the pathogenesis of autoimmune diseases