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Frequent Administration : Diabetic patients requiring 3-4 daily insulin injections, hemophiliacs needing clotting factor replacement, dialysis patients with repeated punctures must prioritize long-term comfort and vascular preservationselect finest possible needle sizes combined with injection site rotation strategies

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Zhang H, Dougherty PM

No adverse events such as endometrial malignancies or hepatotoxicity were reported throughout the follow-up period [173]
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