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Among tyrosine kinase inhibitors, imatinib (a PDGFR inhibitor) and erlotinib (an EGFR inhibitor) induce ROS-dependent apoptosis in melanoma and non-small-cell lung cancer cells, respectively, through disruption of mitochondrial membrane potential upon the stimulation of JNK and p38 phosphorylation 88,89 , while vemurafenib (a BRAF inhibitor) increases the production of superoxide anions with the commensurate depolarization of the mitochondrial membranes in melanoma cells 90

This vital molecule plays a critical role in immune regulationmaintaining what researchers call a delicately balanced intermediate level for optimal lymphocyte function

CCR2 and CXCR3 agonistic chemokines are differently expressed and regulated in human alveolar epithelial cells type II

The pentose phosphate pathway (PPP) is a well-studied source of NADPH, but other pathways such as the pyruvate-isocitrate- -ketoglutarate cycle (involving NADP + -dependent ICDH) and the GABA shunt also play roles (Ratledge, 2014

Therefore, maintaining a pH in physiological ranges is critical for sustained muscle contractions to occur [13]