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For example, leptin has been proposed as an indirect bone cancer promoter, as it induces bone resorption, aiding the aforementioned vicious cycle (80)

Its action via the CB1 receptors located in areas of the brain that are associated with the regulation of nausea, vomiting, and the stress response is thought to be responsible for its antiemetic properties.3234 Cannabidiol is not psychoactive, and unlike THC, acts primarily on the 5HT1A receptors

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Its pathogenesis was ill understood 45, and its treatment was neglected with the anticipation that the patient would eventually recover, albeit over a period of some 1-2 years and after suffering considerable pain, weakness and disability