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Arnulf I, Thomas R, Roy A, Dauvilliers Y

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Nattagh-Eshtivani E, Sani MA, Dahri M, Ghalichi F, Ghavami A, Arjang P, et al

Sunitinib has been approved by the FDA for the treatment of advanced refractory or metastatic gastrointestinal stromal tumors (GIST), cases of GIST with intolerance or resistance to treatment with imatinib mesylate, advanced or metastatic renal cell carcinoma, and unresectable or metastatic pancreatic neuroendocrine tumors.6 It has also been shown to be successful in the treatment of colon and breast carcinomas,7 and there have been reports of cases in which metastatic cutaneous adnexal tumors have stablized.8 Bevacizumab is a recombinant humanized anti-VEGF monoclonal antibody (93% human, 7% murine), available since 2005 for the treatment of colorectal and breast carcinoma, nonsmall cell lung cancer, renal cell carcinoma, ovarian and fallopian tube cancer, and primary peritoneal cancer, in combination with other anticancer agents.9 It is administered by intravenous infusion and exerts its antiangiogenic effect by binding to all the isoforms of VEGF, causing a fall in the number of endothelial cells and in the number of microcapillaries in the tumor tissue, in addition to reducing in vascular permeability.10 Many of the side effects of the antiangiogenic drugs are similar to those caused by traditional chemotherapeutic agents, including skin rash, mucositis, alopecia, xerosis, and pruritus.11 In this review we will focus on the adverse skin reactions most specific to the antiangiogenic drugs (Table 1)