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Description
A patient satisfies the diagnostic criteria for FMS if the following 3 conditions are met: Although the precise mechanisms contributing to the pathophysiology of FMS remain to be fully elucidated, it is thought that patients with fibromyalgia have impaired endogenous analgesic systems, in particular suboptimally functioning descending inhibitory pathways, which normally function to ameliorate pain as well as abnormal pain processing

The proposed mechanisms include upregulation of beta-3 adrenergic receptors in adipose tissue, activation of the cAMP-PKA lipolytic cascade through enhanced catecholamine sensitivity, direct or indirect inhibition of acetyl-CoA carboxylase (ACC) reducing de novo lipogenesis by approximately 43-57% in vitro, and activation of hormone-sensitive lipase (HSL) with increased glycerol release

The STEP trials demonstrated that semaglutide promotes greater fat loss than muscle loss, which may help preserve metabolically active tissue

For this reason, L-Lysine must be obtained from food and other sources
There are no FDA-approved HCG products for weight loss, and the FDA requires prescription HCG labeling to state it has not been shown to increase weight loss, improve fat distribution, or reduce hunger
