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The weekly amount depends on where you are in the ladder: 2.5 mg to start, with 5, 10, and 15 mg being documented maintenance options

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In future trials it will be important to keep track of comorbidities for clinical trial design, either for the purpose of post hoc subgroup analysis or a priori subgroup recruitment, since the neuroathophysiological mechanisms in IC/ BPS patients with different co-morbidities are likely to be different
[Google Scholar] 88.Natarajan R, Ghosh S, Grogan W

The exact duration of the effects depends on your individual metabolism and the degree of B12 deficiency
