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In contrast, when facing pathological attack, neuroglial cells upregulate neuroprotection and mount an evolutionary conserved active defensive response known as reactive gliosis

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doi: 10.3389/fpubh.2022.996179

When exogenous glutamine is depleted, AML cells significantly upregulate the expression of key SSP enzymes such as PHGDH, compensating for metabolic deficits by enhancing de novo serine synthesis to sustain cell survival and proliferation (94)

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