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The receptors for the natriuretic factors are integral plasm membrane proteins, whose intracellular domains possess intrinsic guanylate cyclase activity that catalyzes the formation of cGMP from GTP following natriuretic factor-binding

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Fatty acids can also undergo -oxidation by action of a microsomal oxidase that uses molecular oxygen, and both an alcohol and aldehyde dehydrogenase to produce dicarboxylic acids, molecules with a carboxyl group at each end [75, 76]