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In addition, all studies were carried out in compliance with the ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines ( The protocols were approved by the Animal Care and Use Committees of the University of Virginia and Case Western Reserve University

Metabolomic analysis of follicular fluid from clinical PCOS patients revealed mitochondrial dysfunction, oxidationreduction potential imbalance, and increased oxidative stress in cumulus cells (122)

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Skalny AA, Tinkov AA, Medvedeva YS, Alchinova IB, Karganov MY, Skalny AV et al (2015) Effect of short-term zinc supplementation on zinc and selenium tissue distribution and serum antioxidant enzymes

It also remains unclear how this intervention compares to other interventions