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[DOI] [PMC free article] [PubMed] [Google Scholar] 98.Malik U., Barik A

Authors noted antiaging efficacy of their highly stable SOD with evidence in organ, tissue, cell, and molecular levels from both in vivo testing and in vitro experiments.42 However, these results have not been replicated and other studies emphasize clinical evidence for SODs efficacy is limited and far from being demonstrated.43 Back to the discussion of hormetic effects, in some cases, the benefits of supplemental SOD are either murky at best or even harmful in exacerbating cell injury and death

T cell activity and proliferative potential are markedly inhibited by lactic acid accumulation in the microenvironment (for more information, see the previous section)