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doi: 10.1038/s41419-018-0610-1 103 Fard-EsfahaniPFard-EsfahaniASaidiPFayazSMohabatiRMajdiM

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10.1016/j.pharmthera.2023.108373 19 DaiZ.XinH.FuQ.HaoH.LiQ.LiuQ.et al (2019)

Constitutive activation of NRF2, mainly via loss-of-function mutations in the CUL3-adapter KEAP1 or gain-of-function mutations in NFE2L2 , is thought to provide a fitness advantage to tumor cells in confronting metabolic/oxidative stress resulting from dysregulated growth (DeNicola et al, 2011

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