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Early onset of pathological polyploidization and cellular senescence in hepatocytes lacking RAD51 creates a pro-fibrotic and pro-tumorigenic inflammatory microenvironment

Accelerated thiamine metabolism is observed in hypermetabolic states, e.g., during withdrawal from alcohol, convulsions, infections, diabetes, or a rapidly developing neoplastic disease, especially of the gastrointestinal tract and the hematopoietic system [5153]

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Additionally, tributyrin supplementation has been associated with an increase in beneficial gut bacteria, such as Rikenellaceae , Bacteroides , and Ruminococcaceae , as well as improvements in ileal morphology, plasma GLP-2 concentration, and post-weaning body weight [53,54,55,56,57]

These findings highlight the strong association between hypothalamic inflammation and the etiology and phenotype of PCOS, suggesting that targeting hypothalamic inflammation could be a potential therapeutic strategy (91)