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While the gluten-free diet has been found to improve Hashimotos symptoms and reduce the autoimmune attack on the thyroid, its important to note that selenium deficiency can be caused or worsened by gluten and grain-free diets, as demonstrated in nutritional studies involving people with celiac disease

The importance of an accurate description of the association between the use of metformin and vitamin B12 comes from the significance of the clinical manifestations of vitamin B12 deficiency and its impact on the quality of diabetic patients life

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