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The accumulation of AEGs and their binding to the receptor for glycosylation end-products (RAGE) promotes oxidative stress, which activates the NF-B signalling pathway, upregulates the expression of target genes and triggers inflammation (22)

Nutrigenomic influence of a curcumin-supplemented high glycemic diet on hippocampal microvasculature in male C57BL/6J mice Frontiers in Nutrition, Nutrition, Psychology and Brain Health | February 2026Curcumin, a dietary polyphenol primarily derived from turmeric, has potent antioxidant and anti-inflammatory capabilities against diet-related chronic diseases

Pentostatin is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute nonlymphocytic leukemia and hairy cell leukemia

Second, more attention should be directed toward the roles of non-coding RNAs and epigenetic modifications in hormone-mediated remodeling of melanocyte function, which may help reconcile contradictory findings and offer novel molecular targets

Moreover, previous evidence suggests that telomere length is strongly inherited from ones mother
