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The answer is a resounding yes
Declining levels directly impair oxidative phosphorylation and ATP production (Stein & Imai, 2012)

Treatment often involves dietary changes or vitamin B12 supplements.

"Within about four weeks of having the jab I would start going downhill again - my memory would go, I would start feeling really tired." Ms McDonald buys the B12 jabs from Germany

Using one needle for both caused itch problem