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This Review provides an overview of UPS-mediated proteostasis, focusing on the involvement of the UPS in renal physiology and pathophysiology.

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Competitive Displacement: FOXO4-DRI mimics the binding site of FOXO4. It binds to p53 with high affinity, displacing the endogenous FOXO4

Therefore, our finding highlights a novel aspect of STAT3/GIV pathway in the IL-17 promotes tumor angiogenesis of NSCLC.