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In a notable study, A-C intersubunit crosslinking in GluA2 homotetramers was found to occur in a state-dependent manner and to trap the receptor in a partially activated and apparently partially liganded state 71 , potentially similar to the partially liganded pre-active intact state we observe for GluK2/GluK5 in this study

(PDF) Abbreviations 5,10-methyleneTHF: 5,10-methylenetetrahydrofolate THF: tetrahydrofolate DHF: dihydrofolate dUMP: deoxyuridine monophosphate dTMP: deoxythymine monophosphate 5-methylTHF: 5-methyltetrahydrofolate cSHMT: cytosolic serinehydroxymethyl transferase mSHMT: mitochondrial serinehydroxymethyl transferase MTHFR: methylenetetrahydrofolate reductase TYMS: thymidylate synthase DHFR: dihydrofolate reductase Declarations Conflict of interest The authors have no conflict of interests related to this publication

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