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Oxidative stress is one such external stimulus that disturbs the prooxidant/antioxidant equilibrium due to the loss of control over singling pathways which destroy the bio-molecules ( The Nrf2/ARE pathway is regulated by the circadian clock and is essential for oxidative stress management in our body ( Disruption of Nrf2-Mediated Antioxidant Responses Resulting in Carcinogenesis The internal metabolism and exposure to external stimuli generate reactive oxygen species (ROS) and reactive nitrogen species (RNS) constantly in the body

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doi: 10.1038/s41598-018-29313-w [DOI] [PMC free article] [PubMed] [Google Scholar] 96.Millman AC, Salman M, Dayaram YK, Connell ND, Venketaraman V

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