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Overall, natural compounds show minimal systemic or organ toxicity at therapeutic doses, although mild side effects may occurcurcumin, for instance, has resulted in only minor gastrointestinal upset even at high doses [22, 30, 57]

Temperature rise in the sonicated liquid is to be explained by the second law of thermodynamics, which states that any energy applied finally is converted into heat

[DOI] [PMC free article] [PubMed] [Google Scholar] 61.Schieber M, Chandel NS

The lack of regulatory oversight raises concerns about the quality, safety, and labeling accuracy of commercial probiotics, particularly for vulnerable populations