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Preclinical studies in animals have shown that opioid peptides do not induce central side effects [255,256,257], positioning them as a potentially effective and safe alternative to conventional analgesicsmany of which (e.g., diclofenac) impair wound healing or have a limited systemic penetration but still carry a risk of central nervous system (CNS) side effects (as is the case with regular opioids)

Food supplements should not be intended as a substitute for a varied and balanced diet

Food Sci Technol Res 17, 103110

PMID: 23298508.

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