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Description
Subsequently, around the 8090s, Costa, Furness, and colleagues conducted an extensive series of immunohistochemical and electron microscopy studies to group enteric neurons based on their distinct neurochemistry, projection patterns, and ultrastructure [16,17,18,19,20,21,22,23,24,25,26,27,28,29]

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However, despite promising efficacy and safety data, it did not advance to Phase 3 trials or obtain regulatory approval for therapeutic use

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