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The observation that this phenomenon is absent in ancestral disulfide archaeal enzymes which are produced in organism lacking GSSG and glutathione (GSH) 9 like the Sulfolobus solfataricus Bacterioferritin Comigratory Protein 1 (Bcp1) 10,11 and Protein Disulfide Oxidoreductase ( Ss PDO) 12,13 will give some possible interpretation for the presence or absence of this property in proteins

Most of these toxicological studies point to oxidative stress as a general mechanism of the toxic effect of ZEN (Table 4)

doi: 10.2337/db08-1637

[DOI] [PMC free article] [PubMed] [Google Scholar] 23.Ackara, O

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