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Drug-like properties and the causes of poor solubility and poor permeability

A trained clinician does this routinely

Paradoxically, while normal prostate physiology prioritizes polyamine synthesis (e.g., spermine), regulated by androgen-dependent enzymes like ODC to support secretory functions, PCa progression exhibits a contradictory polyamine landscape: spermine levels decline sharply despite ODC overexpression, a phenomenon contrasting with polyamine accumulation patterns in other cancers

Possible side effects include bruising, mild swelling, transient soreness, and (rarely) infection at the injection sites

Many studies reported a substantial improvement in daily OFF time and fluctuations regarding motor outcomes