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Another possibility is the following: after uptake, vitamin B12 is slowly bound to serum vitamin B12 proteins ( The mechanism by which vitamin B12 administration exerts its positive effect on ME/CFS patients is unknown

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Schmid R, Bruneton J, Hatton CK

With flexible learning options, small class sizes, and ongoing support even after your course, we ensure that every student receives the individual attention they deserve

And some who supplement with it say they feel born again. Sounds pretty promising