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Focus on absorption and quality to get the most out of these powerful compounds

In most cases, B12 deficiency is actually caused by malabsorption rather than low dietary intake

The MTHFR enzyme is responsible for converting tetrahydrofolate into 5-methyltetrahydrofolate (5-MTHF), and reduced enzyme activity may influence methylation efficiency, particularly if riboflavin (vitamin B2) status is suboptimal

this may be because NMN first requires dephosphorylation into NR before uptake into cells 39

Jafaripour L, Naserzadeh R, Alizamani E, Mashhadi SMJ, Moghadam ER, Nouryazdan N, Ahmadvand H (2021) Effects of rosmarinic acid on methotrexate-induced nephrotoxicity and hepatotoxicity in Wistar rats
