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These improvements correlated with increased follicular copper levels and enhanced keratinocyte proliferation

Nature (2012) 486(7404):54953
Nephrotoxicity of nonsteroidal anti-inflammatory drugs: Physiologic foundations and clinical implications

What rodent data can't tell us: species-specific differences in NNMT expression and NAD+ salvage pathways mean rats may tolerate prolonged NNMT inhibition differently than humans

Some users report that the copper component can cause temporary stinging at the injection site
