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doi: 10.1098/rsob.230014 53 SinDD

By inhibiting the functioning of this enzyme, 5-Amino 1MQ promotes a healthier energy metabolism within cells, helps prevent unnecessary fat storage, and encourages the rejuvenation of aging cells

Representative histograms of Annexin V staining gated on live cells (PI ) (left) and quantification of Annexin V + PI cells (right) ( n = 3)

In contrast, when GSDMC expression is upregulated, it becomes the preferred substrate of caspase-8, and its cleavage products directly trigger pyroptosis, thereby hijacking the classical apoptosis-inducing signal [300]