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Annals of the Rheumatic Diseases, 35 , 289295

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5 CA IX regulation and expression pattern CA IX is one of the best responders to low oxygen (ranging from anoxia to moderate hypoxia), mainly because the CA IX-encoding gene (according to the nomenclature designated as CA9 ) is transcriptionally regulated through HIF-1 binding to HRE consensus sequence localized just in front of the transcription initiation site, under conditions of HIF-mediated nucleosomal disassembly [36, 37]

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