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Although GLO1 is reported to be higher expressed in a number of different cancer types including the lung 37,52,53 , in our cohort of 70 patients we did not observe such a clear trend: almost half of the patients had a higher and the other half a lower GLO1 protein expression in tumor compared to the surrounding healthy tissue (Fig

Biochim Biophys Acta 1864:13151321 Lallement PA, Meux E, Gualberto JM, Dumarcay S, Favier F, Didierjean C, Saul F, Haouz A, Morel-Rouhier M, Gelhaye E, Rouhier N, Hecker A (2015) Glutathionyl-hydroquinone reductases from poplar are plastidial proteins that deglutathionylate both reduced and oxidized glutathionylated quinones

investigated the pharmacological modulation of mitochondrial function in intestinal diseases, including CRC, offering insight into mitochondrial dynamics and bioenergetics [25]

It has been demonstrated that some mimetic metallo-complexes may be effective in the mitochondrial matrix, however, due to the relatively easy change of the oxidation state of a metal center, their potential prooxidant properties have to be considered

Here, we expand the picture by examining key stress response pathways that detect and respond to protein misfolding or upstream stress signals