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10.1016/j.ajhg.2013.07.022 Summary Keywords cobalamin, hydroxocobalamin, cyanocobalamin, vitamin B12, metabolic Citation Elangovan R and Baruteau J (2022) Inherited and acquired vitamin B12 deficiencies: Which administration route to choose for supplementation

This is because

RLS symptoms are relieved through movement, and the condition can significantly disrupt sleep qualitypotentially for an extended time as the condition goes undiagnosed or untreated

and its undermining the potential of what may otherwise be effective drugs because responding to a placebo is not necessarily proof that a given treatment doesnt work

When it comes to B12 supplements, the method you choose can make a big difference in the amount of vitamin B12 your body actually receives