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Thanks to these promising preclinical results, a CNTF derivative was tested in clinical trials in which significant weight loss was observed 17,18 , indicating that activation of the CNTFR can regulate food intake and metabolism
For some agents, antioxidant activity may contribute to their efficacy, but therapeutic doses are frequently too low to elicit a meaningful antioxidant response
Cancer 16, 582598
10.1073/pnas.47.10.1588
