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EITC has been found to be a stronger contact sensitizer than PITC in the in vivo model LLNA

Rodrguez-Fernndez B, Vilor-Tejedor N, Arenaza-Urquijo EM, Snchez-Benavides G, Surez-Calvet M, Operto G, Minguilln C, Fauria K, Kollmorgen G, Suridjan I, de Moura MC (2022) Genetically predicted telomere length and Alzheimers disease endophenotypes: a Mendelian randomization study

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This is the first time the active substance is metabolised in the liver, which is called the first pass metabolism

However, if they differentially stabilize oxidation of free GSH to GSSG, then we would expect to see differences in the level of free GSH measured in the heparinized versus EDTA-treated plasma