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The authors underlined that this could be mediated by the reduction in caspase-3/7 activity, by the increase in the B-cell lymphoma 2/BCL-2-like protein 4 (BCL2/BAX) ratio and by the reduction in tumor protein 53 (TP53), caspase-3 (CASP3) and caspase-8 (CASP8) expression [82]
The clinic is hygienic, the staff is very supportive, and the process was completely painless
The Global Response Assessment Questionnaire was utilized to evaluate the patients perception of the effectiveness of this therapy and all 12 patients responded with a score corresponding to significant improvement

Vingerhoets, D.H.Y

2 Methods 2.1 Search strategy The present systematic review adhered to the guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) (Figure 1
