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Two failed to find any anti-cancer benefits, since oral administration of vitamin C was used, which is not sufficient to achieve plasma high-dose vitamin C [88,89]

The metabolic profile of autistic patients has been shown to be abnormal with elevated biomarkers that indicate chronic oxidative stress and evidence that GSH synthesis may be insufficient to maintain redox homeostasis [14, 15]

Supplementation with an TPh-high TPh-low composition decreased inflammatory markers and airway hyperreactivity (AHR) [110] and improved lung function parameters, such as forced expiratory volume in 1 s (FEV1), in well-controlled allergic asthmatics [111]

doi: 10.1016/S1386-5056(97)00094-4

5.3 The challenge of clinical translation 5.3.1 Lack of large-scale randomized controlled trials (RCTs) The potential of functional food active ingredients in combating conditions such as cancer has received widespread attention at the in vitro and animal levels, but high-quality human evidence is relatively scarce