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Feb 3 2006;340(1):291-295
It's a relentless, often frustrating problem, and conventional solutions don't always provide the complete relief people are desperately seeking
However, intranasal administration is also considered an efficient route for systemic effects due to the dense vasculature of the nasal mucosa
Common underlying causes of these progeria syndromes are genomic instability, compromised nuclear envelope, defective mitosis and oxidative stress as a result of accumulated reactive oxygen species (ROS)
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